GE Whatman* DMPK Cards

FTA DMPK-A, FTA DMPKB, and FTA DMPKC cards are designed for dried blood spot (DBS) microvolume sampling. FTA DMPKA and FTA DMPKB cards lyse cells and denature proteins on contact. FTA DMPKC card is not impregnated with chemicals and may be better suited for protein-based biomolecules. Samples spotted on cards can be shipped and stored at ambient temperature. Long-term stability has been demonstrated for analytes and metabolites sensitive to plasma enzymes.

• On-substrate cleanup has the potential to convey greater analyte stability, especially for enzyme-sensitive compounds.
• Fewer experimental animals are required because Toxicokinetic data are derived from Toxicology animals, thereby eliminating satellite colonies.
• Room temperature stability saves on cost of dry ice shipments.
• More consistent data are obtained through more serial sampling from individual animals and less reliance on composite data.
• The 3-step DBS procedure is much more straightforward than the cumbersome centrifugation, isolation and cleanup of plasma.
• Shipping without dry ice allows more remote sampling.
• DBS microvolume sampling requires only 10 to 20 l per sample.
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