Thermo Scientific* ProPac* WCX-10 LC Columns

Use Thermo Scientific ProPac WCX-10 LC Columns to provide exceptionally high resolution for separations of proteins and their variants. Based on stationary phases composed of 10µm non-porous polymeric beads, ProPac columns resolve isoforms that differ by a single charged residue. A thin, hydrophilic layer grafted to the particle core eliminates unwanted secondary interactions. The cation-exchange surface provides pH-based selectivity control and fast mass transfer for high-efficiency separation and moderate capacity.

Multiple Formats for Greater Flexibility
• ProPac WCX-10 column is a weak cation-exchanger with a carboxylate functional group
• Column sizes range from 2 mm I.D., for analytical work, up to 22 mm I.D. for semi-prep work

Superior Performance for Protein Analysis
• Ideal for characterization and quality control assessment of MAbs and other proteins
• Well-suited for characterization of related protein variants including deamidation and MAb lysine truncation variants
• Unequaled high-resolution separations
• Unmatched column-to-column and lot-to-lot reproducibility eliminates column variability as a concern in stability and QA/QC testing

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Flow Rate (mL/min): 0.25
Max Pressure (psi): 3000
Compatibility: Cationic Detergents
Packing Material: Spherical, Non-Porous Polymer
Particle Size (µm): 10
Temperature ( DEG C): 60
Pore Size: Non-Porous
pH: 2 to 12
Stationary Phase: Carboxylate
Length (mm): 250
Technique: Protein/Cation Exchange
Diameter (mm): 2

Flow Rate (mL/min): 1
Max Pressure (psi): 3000
Compatibility: Cationic Detergents
Packing Material: Spherical, Non-Porous Polymer
Particle Size (µm): 10
Temperature ( DEG C): 60
Pore Size: Non-Porous
pH: 2 to 12
Stationary Phase: Carboxylate
Length (mm): 250
Technique: Protein/Cation Exchange
Diameter (mm): 4

Flow Rate (mL/min): 1
Max Pressure (psi): 3000
Compatibility: Cationic Detergents
Packing Material: Spherical, Non-Porous Polymer
Particle Size (µm): 10
Temperature ( DEG C): 60
Pore Size: Non-Porous
pH: 2 to 12
Stationary Phase: Carboxylate
Length (mm): 50
Technique: Protein/Cation Exchange
Diameter (mm): 4

Flow Rate (mL/min): 5
Max Pressure (psi): 3000
Compatibility: Cationic Detergents
Packing Material: Spherical, Non-Porous Polymer
Particle Size (µm): 10
Temperature ( DEG C): 60
Pore Size: Non-Porous
pH: 2 to 12
Stationary Phase: Carboxylate
Length (mm): 250
Technique: Protein/Cation Exchange
Diameter (mm): 9

Max Pressure (psi): 3000
Particle Size (µm): 10
Temperature ( DEG C): 60
pH: 2 to 12
Stationary Phase: Carboxylate
Length (mm): 50
Technique: Protein/Cation Exchange
Diameter (mm): 2

Max Pressure (psi): 3000
Particle Size (µm): 10
Temperature ( DEG C): 60
pH: 2 to 12
Stationary Phase: Carboxylate
Length (mm): 50
Technique: Protein/Cation Exchange
Diameter (mm): 4